MnCl2 efficiently catalyzes the condensation of o-phenylenediamine derivatives with 1,2-diketones at room temperature to afford the corresponding quinoxaline derivatives in high yields.
Sudhakaran and Sudhaparimala, “Synthesis and of some phenyl pyrazolo benzothiazolo quinoxaline derivatives”, International journal of pharm tech and research, vol: 1(3), pp.
Metal Complexes of Quinoxaline Derivatives: Review …
Sudhakaran, “Antioxidant and Antiinflammatory Activity Of Some Phenyl pyrazolo Benzimidazolo Quinoxaline Derivatives”, Journal of pharmacy research, vol.
Reynolds at the University of Florida in Gainesville
Gupta, "Synthesis and Antimicrobial Profile of Newer Schiff Bases and Thiazolidinone Derivatives", WASET- International Journal of Chemical, Nuclear, Metallurgical and Materials Engineering, Vol.
Staff Profile - City University of Hong Kong
Fuloria, Synthesis and antimicrobial activity evaluation of some schiff's bases derived from 2-aminothiazole derivatives, Indonesian Journal of Pharmacy, vol.
Colin Raston - Flinders University
– Synthesis of New Chiral Bicyclic 3-hydroxypiperidines – Highly Diastereoselective Ring Expansion of the Azabicyclo[3.3.0]octane System to Chiral Piperidine Derivatives
May « 2017 « New Drug Approvals
AB - MnCl2 efficiently catalyzes the condensation of o-phenylenediamine derivatives with 1,2-diketones at room temperature to afford the corresponding quinoxaline derivatives in high yields.
10 posts published by DR ANTHONY MELVIN CRASTO Ph.D during May 2017
N2 - MnCl2 efficiently catalyzes the condensation of o-phenylenediamine derivatives with 1,2-diketones at room temperature to afford the corresponding quinoxaline derivatives in high yields.
Chapter 33 - Toxicology INTRODUCTION
The biotransformation of alkyl-, alicyclic-, and alkylaryl-substituted pyrazine derivatives (Nos 761–783 and 798) is expected to occur by oxidation of the alkyl side-chains. Methyl-substituted pyrazines are oxidized to yield the corresponding pyrazine-2-carboxylic acids, while 2-amino-3,8-dimethylimidazo[4,5-]quinoxaline (MeIQx), which is a methyl- and ring-substituted pyrazine derivative, is oxidized to yield the corresponding hydroxymethyl derivatives (Turesky et al., 1988; Knize et al., 1989; Sjödin et al., 1989; Wallin et al., 1989). An alternative pathway for pyrazines and the primary pathway for pyrazine (No. 951) itself involves hydroxylation of the pyrazine ring (Hawksworth & Scheline, 1975; Whitehouse et al., 1987; Yamamoto et al., 1987a,b). Products of oxidative metabolism can be excreted unchanged or conjugated with glycine, glucuronic acid, or sulfate before excretion (Caputo et al., 1989; Parkinson, 1996).
Quinoxaline | Wiki | Everipedia
AB - A library of quinoxaline derivatives were prepared to target non-structural protein 1 of influenza A (NS1A) as a means to develop anti-influenza drug leads. An in vitro fluorescence polarization assay demonstrated that these compounds disrupted the dsRNA-NS1A interaction to varying extents. Changes of substituent at positions 2, 3 and 6 on the quinoxaline ring led to variance in responses. The most active compounds (35 and 44) had IC50 values in the range of low micromolar concentration without exhibiting significant dsRNA intercalation. Compound 44 was able to inhibit influenza A/Udorn/72 virus growth.