Asymmetric Synthesis with Organo-Selenium Compounds…


Results and Discussion Our first efforts to synthesize organoselenium compounds actually began with our attempt to make p-XSC according to the published procedure5.

This is mainly due to the easily decomposed of nitrone and organoselenium compounds ..
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Organoselenium compounds are specialized but useful collection of reagents useful in organic synthesis, although they are generally excluded from processes useful to pharmaceuticals owing to regulatory issues. Their usefulness hinges on certain attributes, including (i) the weakness of the C-Se bond and (ii) the easy oxidation of divalent selenium compounds.


in the synthesis of organoselenium compounds with ..

The second section explains the biophysics and biochemistry of organoselenium compounds, as well as selenoproteins.
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Selenium, in the form of organoselenium compounds, is an essential micronutrient whose absence from the diet causes cardiac muscle and skeletal dysfunction. Organoselenium compounds are required for cellular defense against oxidative damage and for the correct functioning of the immune system. They may also play a role in prevention of premature aging and cancer. The source of Se used in biosynthesis is .


Selenium (EHC 58, 1986) - IPCS INCHEM

The final section closes with several chapters devoted to therapeutic and medicinal applications of organoselenium compounds, covering radioprotectors, anticancer agents and antioxidant behaviour.

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In the past two decades, the functionalization of carbon-carbon double bonds with electrophilic organoselenium compounds addition have been received particular attention. The selenenylation reaction is initiated by the formation of seleniranium ion intermediates from alkenes and the selenium electrophile RSeX followed by backside nucleophilic attack, leading to the anti-addition product. The attack of the nucleophile occurs on the carbon atom that has the more stable positive charge, usually the most substituted carbon atom. Addition reactions of various selenium electrophiles with alkenes have been explored in details by using internal and external nucleophiles.

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Selenium, in the form of organoselenium compounds, is an essential micronutrient whose absence from the diet causes cardiac muscle and skeletal dysfunction. Organoselenium compounds are required for cellular defense against oxidative damage and for the correct functioning of the immune system. They may also play a role in prevention of premature aging and cancer. The source of Se used in biosynthesis is .

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is an enzyme with a selenol at its active site. Organoselenium compounds have been found in higher plants. For example, upon analysis of garlic using the technique of combined with (HPLC-ICP-MS), it was found that γ-glutamyl--methylselenocysteine was the major Se-containing component, along with lesser amounts of . Trace quantities of and allyl methyl selenide are found in human breath after consuming raw garlic.