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isolated a levorotatory fatty acid, mycocerosic acid, from the‘‘purified waxes’’ of ().

Gortner WA established that phospholipids are better quantified by phosphorusdetermination than with any other methods ().

Using deuterium, Rittenberg D et al.

Isoniazid is a synthetic derivative of nicotinic acid with anti-mycobacterial properties

Among activators, a variety of endogenously present lipids were described ().

An antiphosphatidylcholine antibody was described in the serum of a patient diagnosed with hemolytic anemia ().

Phosphatidylserine was shown to be recognized by specific antibodies in patients with lupus anticoagulant ().

The "Nod factors" produced in legumes by as a class of signalling molecules was identified as lipo-chitooligosaccharides ().

First demonstration of phosphatidylinositol anchor on the lipopolysaccharides of a prokaryotic species, ( ).

Demonstration of the induction of the synthesis of proteinase inhibitors by methyl jasmonate in a wounded plant but also in nearby plants through the atmosphere ().

First clear demonstration that fatty acids are as unfavorable as saturated fatty acids in raising LDL cholesterol and lowering HDL cholesterol levels ().


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This effect may be one of thestrategies developed by mycobacteria to fight against the host immunity.

A nitro-fatty acid (nitro-oleic acid), naturally produced during myocardialischaemia, was shown to have anti-inflammatory properties and could havetherapeutic actions against myocardial ischaemia/reperfusion injury ().

The pivotal role of dihydrofolate reductase knockdown in the anticancer activityof 2-hydroxyoleic acid is demonstrated ().


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reported the reversed-phase separation of fatty acids by acomplex two-dimensional TLC employing a catalytic hydrogenationon the plate ().

First description of a direct titration method for analytical hydrogenation todetermine precisely the unsaturation of lipids ().

Discovery of O-amino acid (alanyl and lysyl) esters of phosphatidylglycerol in agram-positive bacteria ().

The first GLC analysis of natural triglycerides from milk fat was reported ().

Hematoside, the ganglioside of horse erythrocytes, is the first ganglioside(GM3) whose structure was elucidated ().

The complete structure of sulfatide (sulfated galactosylceramide) was elucidatedincluding the position of the sulfate group attached to the C3 of galactose ().

Methyl jasmonate was discovered in flowers of jasmine and was shown to be afragrant component in the essential oil from these flowers ().

Discovery of diether-type phospholipids in a an extremely halophilic bacteria () ().

First demonstration of the presence of 2-aminoethylphosphonic acid and itsglycerol ester in lipid extractsof the sea anemone, ().

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1961, 83, 3080) made the first total synthesis of arachidonic acid.

Imai J demonstrated that the oxidative desaturation of a saturated fatty acid (palmitic acid) is depressed in diabetic rats ().

Kennedy EP described the general pathways of the glycerolipid biosynthesis in animal cells ().

Bremer J et al.

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They were correctly identified in 1961.

Discovery that mevalonic acid is incorporated quantitatively into cholesterol incell-free systems with loss of carbon dioxide ().

The chemical structure of the cord factor of was established as trehalose dimycolate ().

Discovery of the first polyisoprenoid alcohol, solanesol, in tobacco leaves

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described for the first time the synthesis of mixed acidtriglycerides ().

Description of the specific presence of fatty acids in the depot fats ofruminants in contrast to their absence in non-ruminants ().

The "phospholipid effect" discovered in 1953 is now attributed to aphosphoinositide in connection with phosphatidic acid metabolism(phosphatidylinositol cycle) ().

Barber JM et al.