Phenoxyacetic acid was fed to male rabbits at a dose of 100–200 mg/kg bw, and some animals also received glycine in amounts corresponding to three equivalents of the acid. In this test, 44–72% of the phenoxyacetic acid was recovered unchanged in the urine within 6 h and 82–105% within 24 h. There was no evidence of conjugation with either glucuronic acid or glycine, even when the diet was supplemented with glycine. A rabbit that received an oral dose of 500 mg of the glycine conjugate of phenoxyacetic acid excreted 30% of the dose unconjugated in the urine after 18 h (Levey & Lewis, 1947). In another study, 55% of an oral dose of an unspecified amount of phenoxyacetic acid was recovered in the urine of dogs and 61% in the urine of humans. No evidence for glycine or glucuronic acid conjugation was found (Thierfelder & Schempp, 1917).
Tulane, V.J. & Lewis, H.B. (1933) Studies in the synthesis of hippuric acid in the animal organism. IX. A comparative study of the rate of synthesis and excretion of hippuric and phenaceturic acids by the rabbit. ., 103, 151–160.
Porphyrin and Heme Synthesis and Bilirubin Metabolism
Treick, R.W. & Konetzka, W.A. (1964) Physiological state of and the inhibition of deoxyribonucleic acid synthesis by phenethyl alcohol. ., 88, 1580–1584.