Replacement of the methyl ether protecting groups of the paraâhydroquinone by methoxymethyl groups at Q1 stage proceeded efficiently, and allowed the facile final oxidation to coenzyme Q10 to occur under mild acidic conditions.
Exercise and physical activity
The Effects Of Coenzyme Q10 Supplementation on Performance During Repeated Bouts of Supramaximal Exercise in Sedentary Men.
J Strength Cond Res. 2009.
The objective of this study was to determine the effects of oral coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise. This randomized, double-blind, crossover study was composed of two 8-week periods of supplementation with either 100 mg.d CoQ10 or placebo. Fifteen healthy and sedentary men participated in the study. According to our results, CoQ10 may show performance-enhancing effects during the repeated bouts of supramaximal exercises and CoQ10 might be used as ergogenic aid.Heart Attacks
In a small trial of patients with recent myocardial infarction, Coenzyme Q10 -- used in addition to aspirin and cholesterol-lowering drugs -- decreased the likelihood of further cardiac events for at least one year after the heart attack. The dosage of Coenzyme Q10 used in the study was 60 mg twice daily. Heart Failure.
Coenzyme Q10: Uses, Forms and Dosage Recommendations
Int J Biochem Cell Biol. 2014 Feb 2. Coenzyme Q10 as a therapy for mitochondrial disease. Treatment of mitochondrial respiratory chain (MRC) disorders is extremely difficult, however, coenzyme Q10 and its synthetic analogues are the only agents which have shown some therapeutic benefit to patients. It serves as an electron carrier in the MRC as well as functioning as a potent lipid soluble antioxidant.