Solid and solution studies of ternary copper(II) complexes formed by heteroaromatic N bases and the anion of N, N-bis(2-hydroxyethyl)glycine (bicine)
Bulbophylol-B was isolated from Bulbophyllum kwangtungense Schltr (Orchidaceae) and exhibited versatile biological activities. This natural product was synthesized by employing Wittig and Ullmann reactions as key steps. The intramolecular C-O formation was performed by using 2 equiv. of copper catalyst to give the 7-membered ring product in 89% yield ().
Solid Phase Synthesis Of Trans Bis Glycinato Copper - …
In a simple term, the principles of green chemistry require low “cost” and high “benefit” in organic reactions. As for the Ullmann reaction, it means that less expensive ligands or ligand- or additive-free conditions, reusable catalysts, and shorter reaction time should be selected. In this context, great efforts have been devoted to developing greener and more sustainable synthetic methods for copper-mediated Ullmann coupling reactions.
Bis[N-(2-hydroxyethyl)-N-methylglycinato]copper(II) - …
The 11-oxo-dibenzodiazepine moiety is an important heterocycle frequently found in drug-like compounds., A general method for the synthesis of 5-substituted 11-oxo-dibenzodiazepines via copper-catalyzed Ullmann inter- and intraaminations under very mild conditions was described by Ma and coworkers in 2011. Fourteen examples bearing various functional groups were obtained in moderate to good yields ().
a series of bis(α-substituted glycinato)copper(II ..
In 2010, a simple and practical method for the copper-catalyzed synthesis of benzimidazo[1,2-b]isoquinolin-11-one derivatives was developed by Fu and coworkers. The corresponding products were formed in moderate to good yields under ligand-free conditions ().
In 2012, a facile tandem reaction for the synthesis of 5,12-dihydroindolo[2,1-b]quinazoline derivatives via copper-catalyzed Ullmann-type intermolecular C-C and intramolecular C-N coupling reactions using trans-4-OH-L-proline (L20), as the ligand, was reported by Dong and coworkers ().
Copper glycinate | C4H8CuN2O4 - PubChem
The one-pot synthesis of 1,2,4-benzothiadiazine 1,1-dioxide derivatives via the Ullmann N-arylation of 2-halobenzenesulfonamides with amidines was developed by Fu and coworkers. Comparing to previous methods, this ligand-free protocol was more convenient and economical. Fifteen examples were reported in 65–81% yields ().
Mechanism of the Cis−Trans Isomerization of Bis(glycinato)copper ..
The quinazolinone skeleton is widely present in natural products, and biologically active molecules.– In 2009, Fu’s group reported a ligand-free protocol for the synthesis of quinazolinone derivatives via copper-catalyzed Ullmann coupling of 2-halobenzoic acid with substituted amidines and guanidines under very mild conditions (). The ortho-effect of the carboxylic acid group greatly facilitated the copper-catalyzed formation of the C-N bond.