N2 - Currently, magnetic iron oxide nanoparticles are the only nanosized magnetic resonance imaging (MRI) contrast agents approved for clinical use, yet commercial manufacturing of these agents has been limited or discontinued. Though there is still widespread demand for these particles both for clinical use and research, they are difficult to obtain commercially, and complicated syntheses make in-house preparation unfeasible for most biological research labs or clinics. To make commercial production viable and increase accessibility of these products, it is crucial to develop simple, rapid and reproducible preparations of biocompatible iron oxide nanoparticles. Here, we report a rapid, straightforward microwave-assisted synthesis of superparamagnetic dextran-coated iron oxide nanoparticles. The nanoparticles were produced in two hydrodynamic sizes with differing core morphologies by varying the synthetic method as either a two-step or single-step process. A striking benefit of these methods is the ability to obtain swift and consistent results without the necessity for air-, pH- or temperature-sensitive techniques; therefore, reaction times and complex manufacturing processes are greatly reduced as compared to conventional synthetic methods. This is a great benefit for cost-effective translation to commercial production. The nanoparticles are found to be superparamagnetic and exhibit properties consistent for use in MRI. In addition, the dextran coating imparts the water solubility and biocompatibility necessary for in vivo utilization.
130. Wang YXJ, Quercy-Jouvet T, Wang HH, Li AW, Chak CP, Xuan S, Shi L, Wang DF, Lee SF, Leung PC, Lau CBS, Fung KP, Leung KCF. Efficacy and durability in direct labeling of mesenchymal stem cells using ultrasmall superparamagnetic iron oxide nanoparticles with organosilica, dextran, and PEG coatings. 2011;4:703-15
Nanocs - Magnetic Nanoparticles
19. Narain R, Gonzales M, Hoffman AS, Stayton PS, Krishnan KM. Synthesis of monodisperse biotinylated p(NIPAAM)-coated iron oxide magnetic nanoparticles and their bioconjugation to streptavidin. 2007;23:6299-6304
Atherosclerosis — An Inflammatory Disease
(a) Proposed mechanism of reversible aggregation. (b) Preparation of cross linked dextran sulfate coated iron oxide nanoparticles (CLADIO), functionalized with amine groups and spiropyran (SP). Reproduced with permission with from Ref. . Copyright (2010) American Chemical Society.
All reagents used for the synthesis were ..
Cross linked dextran coated iron oxide nanoparticles (SPIONs) and silica coated gadolinium oxide nanoparticles (SPGONs) have been synthesized as a radiosensitizer in the proton beam cancer therapy.