Schematic of the LLNL continuous flow-synthesis platform."

N2 - A second-year organic chemistry laboratory experiment to introduce students to general concepts of medicinal chemistry is described. Within a single three-hour time window, students experience the synthesis of a biologically active small molecule and the assaying of its biological toxicity. Benzodiazepine rings are commonly found in antidepressant therapeutics, including Valium and Xanax. This experiment involves the one-step synthesis of a1,5-benzodiazepine derivative via the condensation-cyclization of ortho-phenylenediamine with two equivalents of acetone. Following its isolation, the toxicity of the benzodiazepine product is evaluated via a brine shrimp assay, which allows students to rapidly observe differences in biological activity among varying benzodiazepine concentrations.

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A second-year organic chemistry laboratory experiment to introduce students to general concepts of medicinal chemistry is described. Within a single three-hour time window, students experience the synthesis of a biologically active small molecule and the assaying of its biological toxicity. Benzodiazepine rings are commonly found in antidepressant therapeutics, including Valium and Xanax. This experiment involves the one-step synthesis of a1,5-benzodiazepine derivative via the condensation-cyclization of ortho-phenylenediamine with two equivalents of acetone. Following its isolation, the toxicity of the benzodiazepine product is evaluated via a brine shrimp assay, which allows students to rapidly observe differences in biological activity among varying benzodiazepine concentrations.


Schematic of the LLNL continuous flow-synthesis platform.

T1 - Rapid synthesis of etherimides via catalytic arylation of silylated phenols

The continuous flow-synthesis platform is a novel high-throughput method for materials synthesis that can profoundly change the way nanoparticles are synthesized and assembled.4,5 The current methodology for synthesis and assembly of nanoparticles uses serial empirical exploration of reaction conditions; optimization of the process can only occur in the “next round” of experiments.


Accounts and Rapid Communications in Chemical Synthesis ..

Garg S: Microwave-assisted rapid green synthesis of Silver Nanoparticles using Saraca indica leaf extract and their antibacterial potential. Int J Pharm Sci Res 2013: 4(9); 3615-3619. doi: 10.13040/IJPSR. 0975-8232.4(9).3615-19

Rapid solid-state precursor synthesis of materials.

In situ characterization tools, such as absorbance, fluorescence, Raman spectroscopy, electrical, and electrochemical measurement capabilities can be integrated with the system, providing a real-time monitoring of synthesis, assembly, and nano-to-macroscopic property changes.6 External forces, such as electrical, magnetic, acoustic, and sonication fields and temperature can also be integrated into the system, enabling a higher level of control for synthesis and directed assembly of nanoparticles.

Microwave-assisted iodine-catalyzed rapid synthesis …

The continuous flow-synthesis platform also provides a method to probe multitudes of reaction parameters, significantly reducing the time and effort to explore and examine a vast number of reaction conditions and parameters.

Microwave-assisted iodine-catalyzed rapid synthesis of 6H-indolo ..

The exceptional precision of the system in controlling various parameters of material synthesis such as reactant concentrations, reaction time, mixing rates, and temperature, is also an added benefit compared to the limited amount of control afforded by the conventional approach to material synthesis.