from the biosynthesis of purpurogallin)

The rationale behind the design of these compounds is presented, together with the synthetic route to derivatives bearing aromatic and aliphatic esters of the C4′-position hydroxyl group of the purpurogallin framework, as well as biological data obtained from in vitro assays against Plasmodium falciparum and Trypanosoma cruzi .

Chemists report the first total synthesis of the natural product epicolactone ..
Photo provided by Flickr

The reaction rate of purpurogallin synthesis was maximum (2241.94 mg purpurogallin mg−1 CLEC h−1) at a residence time of 3.5 s, when 5 mmol L−1 pyrogallol was used as the substrate.

First Biomimetic Synthesis Of Epicolactone By Chemists

Synthesis of purpurogallone
Photo provided by Flickr

“The biosynthesis of purpurogallin is well understood, and this enabled us to design a scheme for the biomimetic total synthesis of epicolactone. The pathway begins with vanillyl alcohol and leads in only eight steps to epicolactone,” Trauner explains. “This is yet another example of how a structurally complicated natural product is assembled from simple precursors using a reaction cascade.” The synthetic pathway also gives to a related compound called isoepicolactone, which is likely to occur in E. nigrum as well.