Loneliness of mice and men essay

Different patterns of lymphokine secretion have been observed with different subsets of T cells: INF gamma and IL-2 are produced by the Th1 subset, while IL-4, IL-5, and IL-10 are produced by the Th2 subset, as originally documented for cloned CD T-cell lines from mice (Mosmann & Coffman, 1989).

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If God is necessary to us, then to take him out of our lives is to plunge us into the most terrible sense of loneliness and abandonment that mankind can know.

Of mice and men loneliness and companionship essay

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In particular, SCID mice co-implanted with human fetal thymus and liver tissue fragments (SCID/hu mice) offer the possibility of studying the human thymus in vivo in an isolated xenogeneic environment (McCune et al., 1988; Namikawa et al., 1990) and the effects of immunotoxicants on these grafts.

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Studies have been conducted in mice, and to a lesser extent in rats, to investigate the specificity, precision (reproducibility), sensitivity, accuracy, and relevance for the assessment of risk to human health of a variety of measures of immune status.

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PCB treatment was shown to protect mice and rats against Ehrlich's tumour (Keck, 1981) and Walker 256 tumours (Kerkvliet & Kimeldorf, 1977), shown as reduced tumour growth and metastasis after transplantation; in other studies, however, no influence of PCB on tumour-cell implants was reported (Koller, 1977; Loose et al., 1981).

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4.5.2 Transgenic mice The development of molecular genetic techniques has allowed not only the isolation and analysis of specific genes but also the manipulation of embryonic genes.

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The placement of human fetal thymus under the SCID mouse renal capsule, followed by an intravenous injection of fetal liver cells (McCune et al., 1988), and co-implantation of human fetal liver and fetal thymus under the renal capsule of SCID mice (Namikawa et al., 1990) have resulted in reconstitution of SCID/hu mice; the fetal thymic implants increased in size, and were found to be vascularized.

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With this restriction in mind, the outcome of experiments with SCID/hu and SCID/ra mice can be used to compare the sensitivity of the human and rat thymus and can thus yield important information for the process of human risk assessment.