Total synthesis of palytoxin carboxylic acid and palytoxin ..

N2 - The golden era of total synthesis of natural products faced its turning point in the mid-1990s with the completion of the synthesis of palytoxin by Yoshito Kishi and coworkers at Harvard University. Palytoxin is a vasoconstrictor that targets the sodium-potassium pump protein, effectively destroying the ion gradient essential for most cells. During studies toward the synthesis of palytoxin Kishi and coworkers were faced with the challenge to transform aldehyde into trans-allylic alcohol. The total synthesis of palytoxin was reported eight years later by Kishi and co-workers, based on the novel C-C bond-forming reaction. Many scientists agreed that the discovery of novel unexpected transformations a former key validation for natural product synthesis would become rarer as the field progressed. In fact, the discovery of novel synthetic methods and the total synthesis of natural products were no longer considered concurrent endeavors but two distinct fields of research.

and came to a grand culmination with Kishi’s synthesis of palytoxin in the 1990’s.

The golden era of total synthesis of natural products faced its turning point in the mid-1990s with the completion of the synthesis of palytoxin by Yoshito Kishi and coworkers at Harvard University. Palytoxin is a vasoconstrictor that targets the sodium-potassium pump protein, effectively destroying the ion gradient essential for most cells. During studies toward the synthesis of palytoxin Kishi and coworkers were faced with the challenge to transform aldehyde into trans-allylic alcohol. The total synthesis of palytoxin was reported eight years later by Kishi and co-workers, based on the novel C-C bond-forming reaction. Many scientists agreed that the discovery of novel unexpected transformations a former key validation for natural product synthesis would become rarer as the field progressed. In fact, the discovery of novel synthetic methods and the total synthesis of natural products were no longer considered concurrent endeavors but two distinct fields of research.


Because palytoxin is such a large ..

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