Lipid peroxidation - an overview | ScienceDirect Topics

showed that the hemolytic "cobra-lecithide" of Kyes(1903) was lecithin from which one unsaturated fatty acid has beenremoved, they named it "lysocithin" (now lysophosphatidylcholine)().

Schmidt E measured for the first time high serum cholesterol levels in patientswith xanthomatosis thus recognized as an essential hypercholesterolemia ().

Identifying Intracellular Sites of Eicosanoid Lipid Mediator Synthesis with EicosaCell Assays

EicosaCell is a microscopic assay that enables the intracellular detection and localization of eicosanoid lipid mediator-synthesizing compartments by means of a strategy to covalently cross-link and immobilize eicosanoids at their sites of synthesis followed by immunofluorescent-based localization of the targeted eicosanoid.


Intracellular trafficking - WormBook

How this LDL cholesterol is transported to mitochondria in the human placenta is not well understood.

Leukotrienes are important lipid mediators implicated in the regulation of various cellular processes and in disease states as well as homeostasis. Regulation of leukotriene biosynthesis is therefore of considerable interest. Although the levels of expression and catalytic activity of leukotriene-forming proteins have long been recognized as important determinants of leukotriene biosynthesis, it has recently become apparent that their intracellular compartmentalization also affects the integrated output of this biosynthetic pathway. In this minireview, we focus on the unexpected discovery that the nucleus is the key intracellular site for leukotriene biosynthesis and discuss the mechanisms that regulate protein localization and the potential implications of these findings.


Proteins | S-cool, the revision website

One important model for mechanistic studies of endocytosis in focuses on oocytes, which internalize huge quantities of yolk proteins and their associated lipids by clathrin-mediated endocytosis (). This process is most easily followed by fluorescence microscopy using strains that express transgenes encoding the major yolk protein YP-170 (aka ) fused to GFP (; ). YP170-GFP is synthesized in the intestine of adult hermaphrodites and is secreted basolaterally into the body cavity (pseudocoelom). YP170-GFP, like endogenous yolk, is a cholesterol binding/transport protein related to human ApoB-100, the major protein component of serum low-density lipoprotein (LDL). The yolk receptor in is , an LDL-receptor related molecule expressed specifically in the oocytes (; ). contains a typical NPXY internalization motif in its intracellular domain that is known to direct other members of the LDL-receptor family into clathrin-coated pits. Trafficking of yolk and yolk receptors also depends critically upon the activities of the endocytic Rab proteins , , and , known modulators of endocytosis in all eukaryotes (). Thus yolk uptake provides a genetically tractable system for the study of clathrin and Rab dependent transport processes.

Production of Omega-3 and Omega-6 ..

Thus, an alternative idea is that the START domains of StAR and STARD3 differ slightly in their ability to transport cholesterol to mitochondria.

Match The Organelle With Its Function

More than half of intracellular cholesterol is present in late endosomes [] where many cholesterol-binding proteins, such as NPC1, NPC2, and ORP1L, are thought to control cholesterol transport to other compartments.