Protein folding in the endoplasmic reticulum Protein synthesis

After translation, the protein passes into the channels of the rough endoplasmic reticulum (ER) for transportation. The protein is then passed from the rough ER to the Golgi apparatus inside tiny fluid-filled sacs, called vesicles. The Golgi apparatus is a system of , which are responsible for the modification, processing, and packaging of the proteins. The protein may have a carbohydrate added, to form a glycoprotein. The Golgi apparatus packages the protein in a secretory vesicle, which fuses with the cell membrane and releases the protein from the cell.

What is different about the protein that is destined for the rough endoplasmic reticulum?

33) and contains enzymes for lipid biosynthesis, especially the synthesis of phospholipids and steroids. The smooth endoplasmic reticulum forms transition vesicles to transfer molecules produced in the rough ER to the Golgi complex


are concerned with protein synthesis.

The proteins that are synthesized by the ribosomes can then pass through the translocon and enter the lumen of the ER where they can be transported to other locations within the ER.


Granular endoplasmic reticulum participates in protein synthesis.

Spreading throughout some cells, the ER becomes flattened into thin pancakes called , which are very prominent in cells carrying out a lot of protein synthesis.

Types of Endoplasmic Reticulum: ..

In this way, ribosomal subunits and mRNA transcribed off genes in the DNA can leave the nucleus, enter the endoplasmic reticulum, and participate in protein synthesis.

rough endoplasmic reticulum is the site of protein synthesis

The "rough" appearance of the results from the presence of ribosomes that are bound to the cytosolic side of the endoplasmic reticulum membrane. The presence of ribosomes on the RER indicates that it is involved in

endoplasmic reticulum where they are critical in protein synthesis

Another type of endoplasmic reticulum is Sarcoplasmic Reticulum, which is a type of specialized SER that can be found in smooth, as well as striated muscles.

Endoplasmic reticulum protein synthesis? | Yahoo …

Andrea Neuhof, M.M. Rolls, B. Jungnickel, K-U Kalies and T A Rapoport,  Binding of Signal Recognition particle gives ribosome/nascent chain complexes a competitive advantage in endoplasmic reticulum membrane interaction. Molecular Biology of the Cell, 9: 103-115. 1997