The concept of this module is to offer students the opportunity to experience and dissect the process of designing a material which fulfils specific requirements or needs, its synthesis and its characterisation.
Through this process, the module offers the opportunity to host advanced complex organic syntheses (such as asymmetric synthesis) and supramolecular synthesis.
We will illustrate this approach with examples, starting with synthesis of benzene derivatives. Starting point is usually fairly obvious – simple benzene derivatives or perhaps benzene itself.
Multistep Synthesis of Tetraphenylcyclopentadienone ..
This module aims to provide a breadth core understanding of the physicochemical principles behind some of the main analytical techniques and how these can be applied to identify atomic and molecular structures in both inorganic and organic chemistry. It also offers an insight on advanced synthetic methods and how these techniques can be used to explain and interpret structure and reactivity of complex molecules, such as coordination and organometallic compounds.
Multistep synthesis of the SrFeO2F perovskite …
AB - Due to its sensitivity to most synthetic reagents, it is typically necessary to introduce the boronic acid functional group just prior to its utilization. Overcoming this important limitation, we herein report that air- and chromatographically stable MIDA boronates are compatible with a wide range of common reagents which enables the multistep synthesis of complex boronic acid building blocks from simple B-containing starting materials. X-ray and variable temperature NMR studies link the unique stability of MIDA boronates to a kinetic inaccessibility of the potentially reactive boron p-orbital and/or nitrogen lone pair. These findings were collectively harnessed to achieve a short and modular total synthesis of (+)-crocacin C via the iterative cross-coupling of a structurally complex, MIDA-protected haloboronic acid building block.
Simultaneous multistep synthesis using polymeric …
Norbert Stock has received his Ph.D. degree in chemistry with Prof. Schnick in 1998 at the University of Bayreuth and has spent the next 15 months as a postdoc in the groups of Prof. Ferey, Prof. Cheetham, and Prof. Stucky at the University of Versailles and University of California at Santa Barbara. In 2000, he joined the group of Prof. Bein at the Ludwig-Maximilians University of Munich, where he finished his habilitation in 2004. In the same year, he became Professor at the Institute of Inorganic Chemistry at the Christian-Albrechts-University in Kiel. His research interests are within the field of inorganic–organic hybrid compounds. He has been involved in the development and application of high-throughput methods for reactions under solvothermal conditions. Thus, he is interested in the discovery of new hybrid compounds, in understanding their formation, as well as in setting up synthesis–structure relationships.
Simultaneous multistep synthesis using polymeric reagents
The module is constituted of a series of laboratory activities designed to familiarise students with an array of techniques centred around key aspects of inorganic syntheses. Specifically, the module emphasizes stability and speciation methods and their applications to the inorganic chemistry field. All aspects of the module will be supported by associated relevant analytical technologies.