Synthesis of Aspirin: A General Chemistry Experiment

Ferric Chloride Test for Purity Chemical Reagents: .1M HCl, standardized
.1M NaOH, standardized
95% ethanol
Phenolphthalein solution Step 1 Approximately .5g of the synthesized aspirin was weighed and placed into a 250mL Erlenmeyer flask.


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Students are taken through each stage in the synthetic preparation and must make decisions based on the information presented. Exercises aid the students’ practical skills and understanding of the particular chemistry involved. Their answers are automatically stored in an online laboratory note book, which can be printed or accessed with login details. Individuals can obtain their own ten-digit user number for the website, or a teacher can register the whole class at one time.


Synthesis and Decomposition of Aspirin | Chemistry …

The Synthesis and Analysis of Aspirin
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An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. It is the two-step synthesis of aspirin starting from oil of wintergreen. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer. To understand the chemistry, the student must be able to recognize the common molecular framework shared by oil of wintergreen, salicylic acid, and aspirin and to identify the -OH and -CO2 sites where chemical changes occur. The experiment differs in three ways from traditional aspirin synthesis experiments for general chemistry. It is designed to be performed early rather than late; it starts from a naturally occurring material and requires two steps rather than one; and it utilizes FTIR spectroscopy to distinguish among oil of wintergreen starting material, salicylic acid intermediate, and aspirin product. The use of FTIR spectroscopy introduces students to a modern analytical technique that is currently used in research involving aspirin.


Experiments; Advanced Chemistry with Vernier #22: ..

He also synthesized Aspirin because his father, who had severe arthritis, could not tolerate the salicylic acid he was taking for pain relief.
The Kolbe Synthesis for the production of salicylic acid was created by the German chemist Hermann Kolbe.