Inspired by the tautomeric relationship of imidazole and N-heterocyclic carbenes, we have been intrigued about the implications of such carbenes in metalloenzymes. Enzymes are the machinery of all biological transformations, and provide inspiration for designing artificial catalysts. New insights into the mode of action of enzymes is therefore instrumental for developing more competent synthetic catalysts as well as for better understanding natural systems. In collaboration with F. Paradisi (U Nottingham), we have begun to explore carbene binding to metalloenzymes. We have been focusing on blue copper proteins such as azurin and specific mutants of azurin to investigate the possibility of carbene bonding to the copper center, and to evaluate the effect that such bonding entails. While azurin is predominantly involved in electron transfer processes through reversible copper(II) reduction and oxidation, other blue copper proteins are catalytically active in redox transformations of substrates. Hence, these enzymes provide an attractive probe to explore the relevance of carbene bonding on the catalytic performance of the enzyme.
Sussex Research is known worldwide for its custom synthesis and contract R&D capabilities which utilize our core expertise in carbohydrate synthesis and method development. We provide custom synthesis solutions for biopharmaceutical, therapeutic, diagnostic and research applications for development of molecules that incorporate glycotechnology or exploit glycobiology. We excel at oligosaccharide, glycopeptide and glycoconjugate synthesis. All materials produced at Sussex are thoroughly analyzed and characterized on-site via a variety of state-of-the-art spectroscopic techniques including high field NMR and mass spectrometry.
Custom Synthesis, Organic Chemical Synthesis, …
ABSTRACT: A mesoinic pyridylideneamide ligand (PYA) was synthetized and fully characterized and coordinated to an iridium(III) center. This ligand represents the first example of a mesoionic N-donor ligand. Structural and spectroscopic analysis revealed unique properties which were exploited in chemically driven water oxidation catalysis.
Custom Synthesis - Sussex Research Laboratories Inc.
Custom synthesis of carbohydrate derivatives for the chemical and pharmaceutical use is what we do. Glycoteam chemists are specialised in sugar and organic chemistry.
Synthetic Carbohydrate Polymers and Probes - GlycoTech
Vibrant Pharma Inc. is a Canadian based research & development (R & D) facility and contract research organization (CRO) that offers a wide range of services in custom synthesis, contract research projects, and process development for active pharmaceutical ingredients and drug intermediates. Our main goals are to supply high quality building blocks (carbohydrates and amino acids), enzyme substrates, active pharmaceutical ingredients (APIs), API impurity and reference standards, stable isotopes and chiral ligands to serve the advanced chemical synthetic needs of various sectors of academia as well as global pharmaceutical and biotechnology industries. You can find all currently available compounds in our new online catalogue.
Vibrant Pharma supports its clients from the initial drug discovery process through to a product launch by offering cost effective solutions ranging from milligram scale library synthesis to multi-kilogram process development. We also offer personalized service tailored to companies in all stages of the drug-discovery and development process including library design, synthesis, process development and production, and patent and investigational new drug application (IND; CMC section) drafting. Vibrant Pharma will also provide customized reports and related documentation for Canadian pharmaceutical and biotechnology industries to file their SR&ED claims.
GAPDH Gene - GeneCards | G3P Protein | G3P Antibody
Aurora Fine Chemicals offers a full range of services in custom organic synthesis. We have 20 years experience of satisfying the organic synthesis requirements of drug discovery companies and research institutions worldwide. Aurora's chemists are skilled at performing complex, multi-step syntheses and solving difficult chemistry-related problems. Because of our small (or better: concentrated) size and low overheads, we are able to offer prompt quotations, very competitive prices, high quality products and fast delivery.