Theresonance structures for aniline are shown below, where it is shown that thering becomes electron rich, with partial negative charge (carbanion character)at the ortho and para positions, while the nitrogen tends to become electrondeficient (partial positive charge).
Although the oxepin is a postulated structure, the strongest evidence for the formation of the epoxide is the demonstration that the addition of the enzyme epoxide hydrolase to microsomes used to metabolize benzene results in the accumulation of benzene dihydrodiol (Tunek et al., 1978).
Reaction mechanism for synthesis of sulfanilamide from nitro benzene
Additional studies on the effects of long-term exposure to benzene in experimental animals are described in section 7.6 (carcinogenicity) and in Tables 15 to 17.
Benzene, Its Derivatives, and ..
cells (1985) Mouse L5178Y cells -/ Pellack-Walker & Blumer (1986) Unscheduled rat hepatocytes ND/- Probst & Hill DNA synthesis (1985) HeLa cells -/- Barrett (1985) DNA synthesis Hela cells -/- Painter & Howard inhibition (1982) a Without/with an exogenous metabolic activation system; ND = no data b The IPCS CSSTT working group disagreed over data analysis and therefore called the results inconclusive Whereas the results of in vitro studies for mutations by benzene have been largely negative, there is some evidence that treatment of human and animal cells in vitro with benzene can lead to chromosomal abnormalities.
Synthesis of aniline , Hive Chemistry Discourse
(1990), however, reported that they were unable to detect DNA adducts derived from benzene in the rat in vivo, despite having observed them in Zymbal gland cells in vitro, using the 32P-post labelling technique.
benzene, nitrobenzene & aniline are nasty compounds (no joking)
The structure of an adduct formed between p-benzoquinone and deoxyadenosine-3'-phos phate was suggested to be 3'-hydroxy-1,N6-benztheno-2'-deoxy- adenosine-3'-phosphate (Pongracz & Bodell, 1991).
organic chemistry - Does aniline breakdown in …
For example, in bone marrow stromal macrophages, phenol (but not benzene) can be metabolized and in the process inhibit RNA synthesis in macrophages, thus possibly inhibiting the production of the haemopoietic factor (Post et al., 1985).
Does aniline breakdown in groundwater produce benzene
Covalent N-7-phenyl-guanine adducts have been isolated from rat urine after intraperitoneal dosing with 330-400 mg benzene/kg body weight (Norpoth et al., 1988).