2-BENZOYL -3-AMINO-PYRIDINES - Deutsche, Gold …

Semicarbazones present a wide range of biological applications as antitumoral, anticonvulsant, anti-trypanosomal, herbicidal and biocidal agents (Beraldo & Gambino, 2004; Beraldo , 2002; Teixeira , 2003). In some cases complexation to metal ions can improve properties of these ligands, such as and pharmacological activity. Moreover, mechanisms of action of bioactive compounds can involve coordination to metal-containing enzymes (Farrell, 2002). As part of our research aiming to understand the molecular and biological properties of we previously prepared 2-Benzoylpyridine semicarbazone (H2Bz4PS) and its Cu(II) and Zn(II) complexes (Pérez-Rebolledo , 2006). Here we describe the synthesis and of H2Bz4PS (Fig. 1).

01/04/1975 · 2-BENZOYL -3-AMINO-PYRIDINES ..
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(1957) I. The synthesis of pyridine and pyridine 1-oxide substituted alanine derivatives. II. Preliminary investigations of alpha-chymotrypsin catalyzed hydrolyses of acylated amino acid esters at low enzyme concentrations--studies of surface effects. III. The synthesis and rate of acetolysis of 1-bicyclo[2.2.1]heptylmethyl tosylate. Dissertation (Ph.D.), California Institute of Technology.

2-benzoyl-3-amino-6-bromo-pyridine, 2-benzoyl-3- ..

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2-Benzoylpyridine semicarbazone (H2Bz4PS) was prepared by adding portion-wise an aqueous solution containing equimolar amounts (2 mmol) of semicarbazide hydrochloride and sodium acetate to 2-Benzoylpyridine (2 mmol) in ethanol at room temperature. The reaction mixture was kept under stirring for 20 h. The resulting solid was filtered off and washed with distilled water and ether and then dried. H2Bz4PS: Yield: 69.4%. Melting point: 181.5–182.7 °C. Anal. Calc: C, 64.99; H, 5.03; N, 23.32%. Found: C, 64.02; H, 4.95; N, 23.05%.